You can use the negation of the isin() function to select the indices of elements in the big list that are not present in the smaller list.
Here is an example. 'a' is the big list, and 'b' is the smaller list.
>>> import numpy as np
>>> a=np.array([11,12,13,14,15,16,17])
>>> b=np.array([12,14,15,17])
>>> (~np.isin(a, b)).nonzero()[0]
array([0, 2, 5])